АДГ has great value as already it was marked above, in maintenance of osmotic pressure of blood, волюморегуляции. 2. Regulation of water balance and accordingly blood volume, extra- and an endocellular liquid (волюморегуляция) at the expense of change of volume of water deduced with urine. She plays an important role in mechanisms концентрирования urine, is freely filtered in balls. In проксимальном канальце an urea part passively реабсорбируется засчет a gradient of concentration which arises owing to концентрирования urine. Other part of urea reaches collective tubules. In collective tubules under the influence of АДГ occurs реабсорбция waters and concentration of urea raises. АДГ strengthens permeability of a wall and for urea, and it passes in brain substance of a kidney, creating here approximately 50 % of osmotic pressure. From интерстиция on a concentration gradient urea диффундирует in a loop of Genle and arrives again in дистальные канальцы and collective tubules. Thus intranephritic circulation of urea is made. In case of water диуреза всасывание waters in дистальном department нефрона stops, and urea it is deduced more. Thus it экскреция depends from диуреза. Besides, a kidney экскретирует the majority of hormones and other physiologically active substances which are гуморальными regulators of arterial pressure, supporting their necessary level in blood.